Magnesium Bromide → 2-(2,2,2-Trifluoroethoxy)ethan-1-ol
반응식
[F:1][C:2]([F:15])([F:14])[CH2:3][O:4][CH2:5][CH2:6][O:7]C1CCCCO1.[Br-].[Mg+2].[Br-]>C(OCC)C>[F:1][C:2]([F:15])([F:14])[CH2:3][O:4][CH2:5][CH2:6][OH:7]참가 물질
4
실험 절차
Combine 2-tetrahydropyran-2-yloxyethyl 2,2,2-trifluorethyl ether (2 mmol) and magnesium bromide (6 mmol) in diethyl ether (10 mL). After 24 hours, extract with water and then brine. Dry the organic layer over Na2SO4, filter, and concentrate in vacuo to give 2-hydroxyethyl 2,2,2-trifluorethyl ether.
후처리
- extractionextract with water
- dry with materialDry the organic layer over Na2SO4
- filtrationfilter
- concentrationconcentrate in vacuo
출처 및 근거
- ORD 기록
- ord-548a260dea404a5c8c1788cbebc98700
- 출처 데이터셋
- uspto-grants-2001_04
- 특허 번호
- US06211199B1
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