돌아가기
Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 323499생성일: 2026년 10월 26일

1-(3,4,5-Trimethoxybenzyl)-3-(4-fluorophenylmethyl)-3-(3-methanesulfonyloxypropyl)-2-oxopyrrolidine → 1-(3,4,5-trimethoxybenzyl)-3-(3-(4-(1H-benzimidazol-2-yl-amino)piperidin-1-yl)propyl)-3-(4-fluorophenylmethyl)-2-oxopyrrolidine

https://huagongshe.com/reaction/323499

반응식

참여 물질

역할이름HCID투입량
반응물1-(3,4,5-Trimethoxybenzyl)-3-(4-fluorophenylmethyl)-3-(3-methanesulfonyloxypropyl)-2-oxopyrrolidineHCID 18464483—
반응물(1H-benzimidazol-2-yl)(piperidin-4-yl)amine hydriodic acidHCID 86754231—
생성물1-(3,4,5-trimethoxybenzyl)-3-(3-(4-(1H-benzimidazol-2-yl-amino)piperidin-1-yl)propyl)-3-(4-fluorophenylmethyl)-2-oxopyrrolidineHCID 9895457—

반응 단계

Prepare by the method of Example 4.1 using 1-(3,4,5-trimethoxybenzyl)-3-(4-fluorophenylmethyl)-3-(3-methanesulfonyloxypropyl)-2-oxopyrrolidine and (1H-benzimidazol-2-yl)(piperidin-4-yl)amine hydriodic acid salt to give the title compound: Rf=0.55 (silica gel, 2% triethylamine/methanol).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US06211199B1
출처 데이터셋uspto-grants-2001_04
ORD IDord-4ea88337135043f1bb3b8ffebdec68b2
출처 메모uspto-grants-2001_04