Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Azide → 3-Azido-1-benzhydrylazetidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Azide | HCID 33557 | — |
| 반응물 | 1-Benzhydrylazetidin-3-yl 4-methylbenzenesulfonate | HCID 15512651 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 3-Azido-1-benzhydrylazetidine | HCID 15512652 | — |
반응 단계
A solution of 9 (11.5 g, 31.8 mmol) and sodium azide (4.12 g, 64 mmol) in 250 ml of DMF was heated to 70° C. for 24 hours. After cooling to room temperature the solvent was removed in vacuo and the residue partitioned between chloroform and water. The organics were dried over MgSO4, filtered and the solvent removed in vacuo. The crude product was purified by chromatography on silica gel (8:1 hexane: ethyl acetate) afforded the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06214832B1 |
| 출처 데이터셋 | uspto-grants-2001_04 |
| ORD ID | ord-b1217393730944209c1603dc36d443ea |
| 출처 메모 | uspto-grants-2001_04 |