Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phenethylamine → Methyl phenethylcarbamate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phenethylamine | HCID 1001 | — |
| 반응물 | Diethyl Ether | HCID 3283 | — |
| 반응물 | Methyl chloroformate | HCID 6586 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | Methyl phenethylcarbamate | HCID 4380476 | 95% |
반응 단계
To a stirred solution of phenethylamine (75.2 mL, 0.6 mol) and triethylamine (83 mL, 0.6 mol) in THF (500 mL) was added slowly methyl chloroformate (46.2 mL, 0.6 mol) dissolved in THF (50 mL). After the reaction was stirred for an additional 1 h at room temperature, diethyl ether (2 L) and 1 N HC1 (800 mL) was added. The organic layer was washed with water, dried (MgSO4), and concentrated in vacuo to give a clear oil of pure title compound (102 g, 95%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06214841B1 |
| 출처 데이터셋 | uspto-grants-2001_04 |
| ORD ID | ord-277c8eda734142b89fd4a03135086a4c |
| 출처 메모 | uspto-grants-2001_04 |