Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanesulfonyl chloride → 2-(N-methanesulfonyl-4-piperidinyloxy)-5-chloropyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanesulfonyl chloride | HCID 31297 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 5-Chloro-2-(piperidin-4-yloxy)pyridine | HCID 11264329 | — |
| 생성물 | 2-(N-methanesulfonyl-4-piperidinyloxy)-5-chloropyridine | HCID 22719719 | 74% |
반응 단계
5-Chloro-2-(piperidine-4-yloxy)-pyridine (2.13 g; 10 mmol) (preparation of this compound was made as described in WO 99-GB2801), diisopropylethylamine (2.20 ml; 12.5 mmol) and Methanesulfonyl chloride (1.56 ml; 10.1 mmol) gave 2.14 g (74%) of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07427631B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-c6c5a4fe6f4946dfb1331b470ed65b12 |
| 출처 메모 | uspto-grants-2008_09 |