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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0

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Water → (Z)-tert-Butyl 2-(((1-(2-aminothiazol-4-yl)-2-ethoxy-2-oxoethylidene)amino)oxy)-2-methylpropanoate

HRID 323878

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HRID 323878 반응식

[NH2:1][C:2]1[S:3][CH:4]=[C:5](/[C:7](=[N:13]/[OH:14])/[C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.Br[C:16]([CH3:25])([CH3:24])[C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18].C(=O)([O-])[O-].[K+].[K+].O>CN(C)C=O>[NH2:1][C:2]1[S:3][CH:4]=[C:5](/[C:7](=[N:13]/[O:14][C:16]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])([CH3:25])[CH3:24])/[C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1

참가 물질 반응 조건 실험 절차 후처리 출처 및 근거 반응 노트

참가 물질

6

반응물 4

HCID 11430Potassium Carbonate

HCID 90290tert-Butyl 2-bromo-2-methylpropionate

HCID 6401018Ethyl 2-amino-alpha-(hydroxyimino)thiazol-4-acetate

생성물 1

HCID 6242376(Z)-tert-Butyl 2-(((1-(2-aminothiazol-4-yl)-2-ethoxy-2-oxoethylidene)amino)oxy)-2-methylpropanoate

시약·촉매·용매 1

HCID 6228

Dimethylformamide

용매

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온도: 42.5 °C

실험 절차

Ethyl (Z)-2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetate (32.25 g) of Formula (I) is dissolved in N,N-dimethylformamide (258 ml) at room temperature. Tert.-butyl 2-bromoisobutyrate (38.47 g) and anhydrous potassium carbonate (47.61 g) are added and the resulting suspension is heated to 40-45° C. for 20-25 hrs. The reaction mass is cooled to 30-32° C. and it is added slowly to water. The resulting slurry is stirred at 25-30° C. for about one and a half hours. The product is filtered, washed with water and dried under reduced pressure. Yield: 50 g (93.37%), water content <1.0% w/w; Chromatographic purity (HPLC) >98%.

후처리

temperatureThe reaction mass is cooled to 30-32° C.
filtrationThe product is filtered
washwashed with water
customdried under reduced pressure

출처 및 근거

ORD 기록: ord-c6aee0501c804ed8bc2d4714abc14dd8
출처 데이터셋: uspto-grants-2001_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06214997B1

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