Sodium Bicarbonate → (RS)-Clopidogrel

HRID 323894

반응식

HRID 323894 반응식
C12(CS(O)(=O)=O)C(C)(C)C(CC1)CC2=O.[CH3:16][O:17][C:18](=[O:36])[CH:19]([C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=1[Cl:35])[N:20]1[CH2:25][CH2:24][C:23]2[S:26][CH:27]=[CH:28][C:22]=2[CH2:21]1.C(=O)([O-])O.[Na+]>ClCCl>[CH3:16][O:17][C:18](=[O:36])[CH:19]([C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=1[Cl:35])[N:20]1[CH2:25][CH2:24][C:23]2[S:26][CH:27]=[CH:28][C:22]=2[CH2:21]1

참가 물질

4

반응물 2

HCID 516892Sodium BicarbonateHCID 156143992-chlorophenyl(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetic acid methyl ester (-)-camphorsulfonic acid salt

생성물 1

HCID 2806(RS)-Clopidogrel

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To the suspension made of 200 g of (+)-(2-chlorophenyl)(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetic acid methyl ester (−)-camphorsulfonic acid salt and 800 ml of dichloromethane is added 800 ml of sodium hydrogen carbonate solution. After stirring the organic phase is separated by decantation, dried on sodium sulfate and the solvent is removed in vacuo. The (+)-(2-chlorophenyl)(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetic acid methyl ester is obtained as a solution in 800 ml of dichloromethane. After stirring, the organic phase is separated by decantation, dried over sodium sulfate and the solvent is removed in vacuo.

후처리

  1. customis separated by decantation
  2. customdried on sodium sulfate
  3. customthe solvent is removed in vacuo

출처 및 근거

ORD 기록
ord-93f39ecc13554fcdb3469ca7282d9e22
출처 데이터셋
uspto-grants-2001_04
특허 번호
US06215005B1

연결된 노트

불러오는 중…