Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Chloroacetone → (p-Tolylsulphonyl)acetone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Chloroacetone | HCID 6571 | — |
| 반응물 | Sodium toluene-4-sulphinate dihydrate | HCID 23678556 | — |
| 반응물 | Water benzene acetone | HCID 68819625 | — |
| 용매 | Ethylacetate heptane | HCID 21899848 | — |
| 생성물 | (p-Tolylsulphonyl)acetone | HCID 79327 | 95% |
반응 단계
Was prepared according to Crandall et al. J. Org. Chem. 1985, (8) 50, 1327-1329 from sodium p-toluensulfinate dihydrate (4.2 g, 18 mmol), chloroacetone (1.0 mL, 12 mmol), n-tetrabutylammonium bromide (0.30 g) and water-benzene-acetone 4:3:3 (10 mL). Work-up and chromatography on silica of the crude using ethyl acetate/n-heptane (1:3 through 1:2) as eluent gave 2.4 g (95%) of the title product as an oil which crystallised on standing in the fridge.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07427631B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-f7c0cf0c691042ad8dc440d4807c84dd |
| 출처 메모 | uspto-grants-2008_09 |