Benzyl 4-Hydroxybenzoate → Benzyl 4-n-dodecylcarbonyloxybenzoate

HRID 324148

반응식

HRID 324148 반응식
C(N(CC)CC)C.[OH:8][C:9]1[CH:24]=[CH:23][C:12]([C:13]([O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[O:14])=[CH:11][CH:10]=1.[C:25](Cl)(=[O:38])[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37]>C1(C)C=CC=CC=1>[CH2:26]([C:25]([O:8][C:9]1[CH:24]=[CH:23][C:12]([C:13]([O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[O:14])=[CH:11][CH:10]=1)=[O:38])[CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37]

참가 물질

5

반응물 3

HCID 7180Benzyl 4-HydroxybenzoateHCID 8471TriethylamineHCID 87288Tridecanoyl chloride

생성물 1

HCID 22002898Benzyl 4-n-dodecylcarbonyloxybenzoate수율 83%

시약·촉매·용매 1

HCID 1140Toluene용매2회

실험 절차

{circle around (1)}: A solvent comprising 1.1 g of triethylamine and 5 g of toluene was added dropwise to a mixture comprising 2.28 g of benzyl 4-hydroxybenzoate, 2.33 g of n-tridecanoic chloride and 15 g of toluene in 30 minutes while cooling it with ice. After finishing adding dropwise, the mixture was stirred at room temperature for 3 hours. After finishing the reaction, deposited salts were filtered off, and the filtrate was neutralized with ½ N hydrochloric acid and washed with water. Then, toluene was distilled off under reduced pressure, and the resultant residue was recrystallized from ethanol, whereby 3.52 g of benzyl 4-n-dodecylcarbonyloxybenzoate was obtained in the form of a colorless crystal.

후처리

  1. temperaturewhile cooling it with ice
  2. additionAfter finishing adding dropwise
  3. customthe reaction
  4. filtrationwere filtered off
  5. washwashed with water
  6. distillationThen, toluene was distilled off under reduced pressure
  7. customthe resultant residue was recrystallized from ethanol

출처 및 근거

ORD 기록
ord-5474de2af51041589549d0ca30e02ea1
출처 데이터셋
uspto-grants-2001_04
특허 번호
US06217793B1

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