Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetone → 3-Chloro-N-[1-(2-chlorophenyl)-2-(1-isopropylpiperidin-4-yl-methoxy)ethyl]-1H-indole-6-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetone | HCID 180 | — |
| 반응물 | 3-chloro-N-[1-(2-chlorophenyl)-2-(piperidin-4-ylmethoxy)ethyl]-1H-indole-6-carboxamide | HCID 69307888 | — |
| 생성물 | 3-Chloro-N-[1-(2-chlorophenyl)-2-(1-isopropylpiperidin-4-yl-methoxy)ethyl]-1H-indole-6-carboxamide | HCID 44444065 | — |
반응 단계
Using alkylation method A, 3-chloro-N-[1-(2-chloro-phenyl)-2-(piperidin-4-ylmethoxy)ethyl]-1H-indole-6-carboxamide (200 mg, 0.41 mmol) and acetone (2.5 mL, 54 mmol) afforded, after purification (SiO2: 10:10:1 hexane:EtOAc:isopropylamine), 132 mg (66%) of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07427632B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-a3a79da5ed294cd4a7b8adeef645bf4d |
| 출처 메모 | uspto-grants-2008_09 |