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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 32425생성일: 2026년 10월 26일

Acetaldehyde → 3-Chloro-N-[1-(2-chlorophenyl)-2-(1-ethylpiperidin-4-yl-methoxy)ethyl]-1H-indole-6-carboxamide

https://huagongshe.com/reaction/32425

반응식

참여 물질

역할이름HCID투입량
반응물AcetaldehydeHCID 177—
반응물3-chloro-N-[1-(2-chlorophenyl)-2-(piperidin-4-ylmethoxy)ethyl]-1H-indole-6-carboxamideHCID 69307888—
생성물3-Chloro-N-[1-(2-chlorophenyl)-2-(1-ethylpiperidin-4-yl-methoxy)ethyl]-1H-indole-6-carboxamideHCID 44444086—

반응 단계

Using alkylation method A, 3-chloro-N-[1-(2-chloro-phenyl)-2-(piperidin-4-ylmethoxy)ethyl]-1H-indole-6-carboxamide (600 mg, 1.3 mmol) and acetaldehyde (0.4 mL, 6.7 mmol) afforded, after purification (SiO2: 10:10:1 hexane:EtOAc:isopropylamine) and recrystallization (acetonitrile), 275 mg (43%) of the title compound.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07427632B2
출처 데이터셋uspto-grants-2008_09
ORD IDord-17395d43aa494cd5984f29920228c68a
출처 메모uspto-grants-2008_09