Sodium Bicarbonate → Clavulanic Acid
반응식
[CH2:1]1[C:4](=[O:5])[N:3]2[C@@H:6]([C:12]([O:14]CC3C=CC=CC=3)=[O:13])/[C:7](/[O:11][C@H:2]12)=[CH:8]/[CH2:9][OH:10].C(=O)([O-])O.[Na+]>C(O)C.[Pd]>[CH2:1]1[C:4](=[O:5])[N:3]2[C@@H:6]([C:12]([OH:14])=[O:13])/[C:7](/[O:11][C@H:2]12)=[CH:8]/[CH2:9][OH:10]참가 물질
5
실험 절차
Substantially pure benzyl clavulanate (281 mg) in ethanol (25 ml.) containing sodium hydrogen carbonate (82 mg.) was hydrogenated over 10% Pd/C (90 mg.) for 25 minutes at room temperature and atmospheric pressure. The catalyst was filtered off, washed with water and ethanol, and the combined filtrates evaporated under reduced pressure at room temperature. The residual semi-solid was triturated with acetone, filtered and washed with ether to yield sodium clavulanate (135 mg.)
후처리
- filtrationThe catalyst was filtered off
- washwashed with water and ethanol
- customthe combined filtrates evaporated under reduced pressure at room temperature
- customThe residual semi-solid was triturated with acetone
- filtrationfiltered
- washwashed with ether
출처 및 근거
- ORD 기록
- ord-085f62fc209f441eac77d837a856ef5d
- 출처 데이터셋
- uspto-grants-2001_04
- 특허 번호
- US06218380B1
반응 노트
불러오는 중…