참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 4-Methoxybenzenesulfonyl chloride | HCID 7401 | — |
| 반응물 | D-Aspartic Acid | HCID 83887 | — |
| 용매 | Sodium Hydroxide | HCID 14798 | — |
| 생성물 | L-Aspartic Acid | HCID 5960 | — |
반응 단계
D-Aspartic acid (2.66 g) is suspended in 2N NaOH (30 mL) and 4-methoxyphenylsulfonyl chloride (4.12 g) is added. The mixture is stirred at 70° C. for 5 hours (clear solution), cooled down to room temperature and extracted with methylene chloride. The aqueous phase, after acidifying with 12N HCl, is extracted with ethyl acetate. The combined organic phases are with brine, dried (Na2SO4) and concentrated under reduced pressure to give N-[4-methoxyphenyl)sulfonyl]-D-aspartic acid as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06218389B1 |
|---|
| 출처 데이터셋 | uspto-grants-2001_04 |
|---|
| ORD ID | ord-de226369a28f4cc8b18b16c2cda762da |
|---|
| 출처 메모 | uspto-grants-2001_04 |
|---|
