Trifluoroacetic acid → HCID 22004376, 화합물

HRID 324348노트

반응식

HRID 324348 반응식
FC(F)(F)C(O)=O.C([O:12][C:13]([CH2:15][N:16]1[N:25]=[C:24]([NH:26][CH2:27][C:28]2[CH:33]=[CH:32][C:31]([O:34][CH3:35])=[C:30]([Cl:36])[CH:29]=2)[C:23]2[C:18](=[CH:19][CH:20]=[C:21]([C:37]#[N:38])[CH:22]=2)[C:17]1=[O:39])=[O:14])(C)(C)C>>[C:13]([CH2:15][N:16]1[N:25]=[C:24]([NH:26][CH2:27][C:28]2[CH:33]=[CH:32][C:31]([O:34][CH3:35])=[C:30]([Cl:36])[CH:29]=2)[C:23]2[C:18](=[CH:19][CH:20]=[C:21]([C:37]#[N:38])[CH:22]=2)[C:17]1=[O:39])([OH:14])=[O:12]

참가 물질

3

반응물 2

HCID 6422Trifluoroacetic acidHCID 220043942-tert-Butoxycarbonylmethyl-4-(3-chloro-4-methoxybenzyl)amino-6-cyano-1(2H)-phthalazinone

생성물 1

HCID 22004376HCID 22004376, 화합물수율 16.7%

실험 절차

Trifluoroacetic acid (5 ml) was added to 0.41 g of the t-butyl ester prepared in Example 22. The obtained mixture was stirred at room temperature for one hour and freed from the trifluoroacetic acid by vacuum distillation. The obtained residue was recrystallized from ethanol/water to give 0.06 g of the title compound as a yellow crystal.

후처리

  1. distillationfreed from the trifluoroacetic acid by vacuum distillation
  2. customThe obtained residue was recrystallized from ethanol/water

출처 및 근거

ORD 기록
ord-d4148c6106ae4272ab77359f5e4d6c28
출처 데이터셋
uspto-grants-2001_04
특허 번호
US06218392B1

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