Dimethylformamide → m-Ethylbenzaldehyde

HRID 324399

반응식

HRID 324399 반응식
Br[C:2]1[CH:3]=[C:4]([CH2:8][CH3:9])[CH:5]=[CH:6][CH:7]=1.C([Li])CCC.CN(C)[CH:17]=[O:18]>O1CCCC1>[CH2:8]([C:4]1[CH:3]=[C:2]([CH:7]=[CH:6][CH:5]=1)[CH:17]=[O:18])[CH3:9]

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 123170Benzene, 1-bromo-3-ethyl-HCID 178418339Butyllithium

생성물 1

HCID 118623m-Ethylbenzaldehyde

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 3-bromo-ethylbenzene (25 g) in dry tetrahydrofuran (350 ml) at −70° C. was treated dropwise with n-butyllithium (59 ml of a 2.5M solution in hexanes) and stirred for 1 hour. N,N-Dimethylformamide (30 ml) was added and the solution was stirred at −70° C. for 1 hour and allowed to warm to room temperature. The reaction mixture was partitioned between saturated ammonium chloride solution and ethyl acetate. The organic phase was washed with 1N hydrochloric acid, dried (MgSO4) and evaporated.

후처리

  1. stirringthe solution was stirred at −70° C. for 1 hour
  2. customThe reaction mixture was partitioned between saturated ammonium chloride solution and ethyl acetate
  3. washThe organic phase was washed with 1N hydrochloric acid
  4. dry with materialdried (MgSO4)
  5. customevaporated

출처 및 근거

ORD 기록
ord-0133cb16fb0d4941a628eec4a0bbb843
출처 데이터셋
uspto-grants-2001_04
특허 번호
US06218376B1

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