Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylformamide → m-Ethylbenzaldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Benzene, 1-bromo-3-ethyl- | HCID 123170 | — |
| 반응물 | Butyllithium | HCID 178418339 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | m-Ethylbenzaldehyde | HCID 118623 | — |
반응 단계
A solution of 3-bromo-ethylbenzene (25 g) in dry tetrahydrofuran (350 ml) at −70° C. was treated dropwise with n-butyllithium (59 ml of a 2.5M solution in hexanes) and stirred for 1 hour. N,N-Dimethylformamide (30 ml) was added and the solution was stirred at −70° C. for 1 hour and allowed to warm to room temperature. The reaction mixture was partitioned between saturated ammonium chloride solution and ethyl acetate. The organic phase was washed with 1N hydrochloric acid, dried (MgSO4) and evaporated.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06218376B1 |
| 출처 데이터셋 | uspto-grants-2001_04 |
| ORD ID | ord-0133cb16fb0d4941a628eec4a0bbb843 |
| 출처 메모 | uspto-grants-2001_04 |