1-Methyluracil → HCID 178432306, 화합물

HRID 324480

반응식

HRID 324480 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[CH:22](O)[C:10]3[N:11]=[C:12]([CH3:21])[N:13]([CH2:14][CH2:15][C:16]4[N:17]=[CH:18][NH:19][CH:20]=4)[C:9]=3[CH:8]=[CH:7][C:6]=2[CH:24]=1.[CH3:25][N:26]1[CH:33]=[CH:32][C:30](=[O:31])[NH:29][C:27]1=[O:28]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[CH:22]([C:32]3[C:30](=[O:31])[NH:29][C:27](=[O:28])[N:26]([CH3:25])[CH:33]=3)[C:10]3[N:11]=[C:12]([CH3:21])[N:13]([CH2:14][CH2:15][C:16]4[N:17]=[CH:18][NH:19][CH:20]=4)[C:9]=3[CH:8]=[CH:7][C:6]=2[CH:24]=1

참가 물질

3

반응물 2

HCID 120091-MethyluracilHCID 178432308(+/-)-7-Chloro-1-((imidazol-4-yl)ethyl)-2-methyl-4h-benzo[5,6]cyclohepta[1,2-d]imidazol-4-ol

생성물 1

HCID 178432306HCID 178432306, 화합물

실험 절차

The subtitle product was prepared from the product of step (ii) and 1-methyluracil (0.36 g) according to the method of example 42 step (iv). Purification was by biotage chromatography on silica eluting with 5% methanol in dichloromethane with 1% 0.880 ammonia present to give a white solid.

후처리

  1. customPurification
  2. customto give a white solid

출처 및 근거

ORD 기록
ord-83fd2bfa2f15441692957c68e4a50d22
출처 데이터셋
uspto-grants-2001_04
특허 번호
US06218376B1

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