Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 324595생성일: 2026년 10월 24일
Tricyclo(3.3.1.1'3,7)dec-1-ylmethanol → tert-Butyl (2S)-(adamant-1-ylmethoxycarbonylamino)-3-tert-butoxycarbonylaminopropionate
https://huagongshe.com/ko/reaction/324595
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Tricyclo(3.3.1.1'3,7)dec-1-ylmethanol | HCID 64556 | — |
| 반응물 | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | (S)-tert-Butyl 2-amino-3-((tert-butoxycarbonyl)amino)propanoate hydrochloride | HCID 86585733 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | tert-Butyl (2S)-(adamant-1-ylmethoxycarbonylamino)-3-tert-butoxycarbonylaminopropionate | HCID 68828668 | — |
반응 단계
A solution of 10.9 g (65.4 mmol) of (1-hydroxymethyl)adamantane and 10.6 g (65.4 mmol) of carbonyldiimidazole in 60 ml of THF is stirred at 50° C. for 1.5 h. 9.7 g (32.7 mmol) of (13.9) in 25 ml of THF and 5.6 ml (32.7 mmol) of diisopropylethylamine (DIPEA) are added and the mixture is stirred at 60° C. for 4 h and then left to stand at room temperature overnight. The solvent is removed in vacuo and the residue is chromatographed through silica gel using heptane/ethyl acetate=7/3. 8.7 9 (59%) of (13.10) are obtained as a colorless oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06218415B1 |
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| 출처 데이터셋 | uspto-grants-2001_04 |
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| ORD ID | ord-792933421eae4e7fbca11c9b232f95ea |
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| 출처 메모 | uspto-grants-2001_04 |
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