Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-(2-(Benzyl(methyl)amino)-1-hydroxyethyl)benzene-1,2-diol → (+-)-Adrenaline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-(2-(Benzyl(methyl)amino)-1-hydroxyethyl)benzene-1,2-diol | HCID 22005903 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Sulfuric Acid | HCID 1118 | — |
| 생성물 | (+-)-Adrenaline | HCID 838 | — |
반응 단계
Benzyladrenaline 2 is dissolved in about 10 ml of water and about 5 ml of 18% sulfuric acid (pH: about 5.5), about 50 mg of palladium-charcoal (10%) are added and the mixture is hydrogenated at about 60° C. under 2 bar of hydrogen pressure. It is then evaporated down to about half its volume, about 20 ml of methanol are added and the mixture is cooled. The crystalline product (adrenaline sulphate 3) is filtered off and dried.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06218575B1 |
| 출처 데이터셋 | uspto-grants-2001_04 |
| ORD ID | ord-0d5d680909424c2b8d92acfc8a968ddf |
| 출처 메모 | uspto-grants-2001_04 |