4-(2-(Benzyl(methyl)amino)-1-hydroxyethyl)benzene-1,2-diol → (+-)-Adrenaline

HRID 324713

반응식

HRID 324713 반응식
[CH2:1]([N:8]([CH2:10][CH:11]([C:13]1[CH:20]=[CH:19][C:17]([OH:18])=[C:15]([OH:16])[CH:14]=1)[OH:12])C)C1C=CC=CC=1.[H][H]>O.S(=O)(=O)(O)O.[Pd]>[CH3:1][NH:8][CH2:10][CH:11]([C:13]1[CH:20]=[CH:19][C:17]([OH:18])=[C:15]([OH:16])[CH:14]=1)[OH:12]

참가 물질

6

반응물 2

HCID 220059034-(2-(Benzyl(methyl)amino)-1-hydroxyethyl)benzene-1,2-diolHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 838(+-)-Adrenaline

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 962Water용매HCID 1118Sulfuric Acid용매

실험 절차

Benzyladrenaline 2 is dissolved in about 10 ml of water and about 5 ml of 18% sulfuric acid (pH: about 5.5), about 50 mg of palladium-charcoal (10%) are added and the mixture is hydrogenated at about 60° C. under 2 bar of hydrogen pressure. It is then evaporated down to about half its volume, about 20 ml of methanol are added and the mixture is cooled. The crystalline product (adrenaline sulphate 3) is filtered off and dried.

후처리

  1. customIt is then evaporated down to about half its volume, about 20 ml of methanol
  2. additionare added
  3. temperaturethe mixture is cooled
  4. filtrationThe crystalline product (adrenaline sulphate 3) is filtered off
  5. customdried

출처 및 근거

ORD 기록
ord-0d5d680909424c2b8d92acfc8a968ddf
출처 데이터셋
uspto-grants-2001_04
특허 번호
US06218575B1

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