참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | HCID 178474238 | HCID 178474238 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Potassium Hydroxide | HCID 14797 | — |
| 생성물 | HCID 178507147 | HCID 178507147 | 57.7% |
반응 단계
Compound 3-(4-acetamidophenyl)-4-aminofuro[2,3-d]pyrimidine 8 (242 mg) was dissolved in 2 M potassium hydroxide in the mixture of EtOH (16 mL) and water (4 mL). The mixture was heated (60° C.) for 24 h then concentrated in vacuo. Residual oil was triturated with cold water (6 mL) to give precipitation, which was filtrated, washed with water, and dried under the reduced pressure. The compound 9 (118 mg) as pale orange colored was obtained. MS(ES) m/e 227M+H].
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07427623B2 |
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| 출처 데이터셋 | uspto-grants-2008_09 |
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| ORD ID | ord-f06b98cc45974b1297cfbef9da28bc0b |
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| 출처 메모 | uspto-grants-2008_09 |
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