HCID 178474238, 화합물 → HCID 178507147, 화합물

HRID 32475

반응식

HRID 32475 반응식
C([NH:4][C:5]1[CH:10]=[CH:9][C:8]([N:11]2[C:16]([NH2:17])=[C:15]3[CH:18]=[CH:19][O:20][C:14]3=[N:13][CH2:12]2)=[CH:7][CH:6]=1)(=O)C>[OH-].[K+].CCO.O>[NH2:17][C:16]1[N:11]([C:8]2[CH:7]=[CH:6][C:5]([NH2:4])=[CH:10][CH:9]=2)[CH2:12][N:13]=[C:14]2[O:20][CH:19]=[CH:18][C:15]=12

참가 물질

5

반응물 1

HCID 178474238HCID 178474238, 화합물

생성물 1

HCID 178507147HCID 178507147, 화합물수율 57.7%

시약·촉매·용매 3

HCID 702Ethanol용매HCID 962Water용매HCID 14797Potassium Hydroxide용매

반응 조건

온도
60 °C

실험 절차

Compound 3-(4-acetamidophenyl)-4-aminofuro[2,3-d]pyrimidine 8 (242 mg) was dissolved in 2 M potassium hydroxide in the mixture of EtOH (16 mL) and water (4 mL). The mixture was heated (60° C.) for 24 h then concentrated in vacuo. Residual oil was triturated with cold water (6 mL) to give precipitation, which was filtrated, washed with water, and dried under the reduced pressure. The compound 9 (118 mg) as pale orange colored was obtained. MS(ES) m/e 227M+H].

후처리

  1. concentrationthen concentrated in vacuo
  2. customResidual oil was triturated with cold water (6 mL)
  3. customto give
  4. customprecipitation, which
  5. filtrationwas filtrated
  6. washwashed with water
  7. customdried under the reduced pressure

출처 및 근거

ORD 기록
ord-f06b98cc45974b1297cfbef9da28bc0b
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07427623B2

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