Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
P-Chloroacetophenone → (1R)-1-(4-chlorophenyl)ethan-1-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | P-Chloroacetophenone | HCID 7467 | — |
| 반응물 | Benzenemethanol, 4-chloro-alpha-methyl- | HCID 18825 | — |
| 반응물 | (1S)-1-(4-chlorophenyl)ethan-1-ol | HCID 6950175 | — |
| 생성물 | (1R)-1-(4-chlorophenyl)ethan-1-ol | HCID 643324 | 58% |
반응 단계
As shown here, the biochemical conversion reaction of immobilized buckwheat protein for the substrate (±)-1-(4-chlorophenyl)ethanol (200 mg) requires 13 days by going through bioconversion to 4-chloroacetophenone accompanying sterically selective oxidation of (S)-1-(4-chlorophenyl)ethanol to obtain 116 mg of (R)-1-(4-chlorophenyl)ethanol at a yield of 58%. Optical purity was obtained at 91% e.e.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06218581B1 |
| 출처 데이터셋 | uspto-grants-2001_04 |
| ORD ID | ord-038178653421481595bc61023e775d66 |
| 출처 메모 | uspto-grants-2001_04 |