4-Chlorobenzonitrile → 4-Chlorobenzene-1-carboximidamide hydrochloride
반응식
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1.C[O-].[Na+].[Cl-].[NH4+:14]>CO>[ClH:1].[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]([NH2:14])=[NH:7])=[CH:4][CH:3]=1참가 물질
5
실험 절차
To a solution of 4-chlorobenzonitrile (5.0 g) in methanol (40 ml) was added sodium methoxide (0.20 g) and the reaction was stirred at room temperature for 3 days. Ammonium chloride (1.94 g) was added and the reaction was stirred overnight. The reaction was filtered and the filtrate concentrated to an oil. After the addition of ether the off-white precipitate was collected and dried to give the title compound (3.62 g). Electrospray MS m/z 155 [M+H]+.
후처리
- stirringthe reaction was stirred overnight
- filtrationThe reaction was filtered
- concentrationthe filtrate concentrated to an oil
- additionAfter the addition of ether the off-white precipitate
- customwas collected
- customdried
출처 및 근거
- ORD 기록
- ord-b654f5a2fedb4bb69a480af9c74c55cc
- 출처 데이터셋
- uspto-grants-2001_04
- 특허 번호
- US06218538B1
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