2,6-Diisopropyl-4-(4-fluorophenyl)-5-pentyl-3-pyridine-carboxaldehyde → 2,6-Diisopropyl-3-ethenyl-4-(4-fluorophenyl)-5pentylpyridine

HRID 324837

반응식

HRID 324837 반응식
[CH2:1]([Li])CCC.[CH:6]([C:9]1[C:14]([CH:15]=O)=[C:13]([C:17]2[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=2)[C:12]([CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])=[C:11]([CH:29]([CH3:31])[CH3:30])[N:10]=1)([CH3:8])[CH3:7]>[Br-].C[P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.C1COCC1>[CH:6]([C:9]1[C:14]([CH:15]=[CH2:1])=[C:13]([C:17]2[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=2)[C:12]([CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])=[C:11]([CH:29]([CH3:31])[CH3:30])[N:10]=1)([CH3:8])[CH3:7]

참가 물질

5

반응물 2

HCID 220049662,6-Diisopropyl-4-(4-fluorophenyl)-5-pentyl-3-pyridine-carboxaldehydeHCID 178418339Butyllithium

생성물 1

HCID 220052272,6-Diisopropyl-3-ethenyl-4-(4-fluorophenyl)-5pentylpyridine수율 66%

시약·촉매·용매 2

HCID 74505Methyltriphenyliphosphonium bromide촉매HCID 8028Tetrahydrofuran용매2회

반응 조건

온도
-78 °C

실험 절차

Methyl triphenylphosphonium bromide was suspended in 15 mL of dry THF under argon and stirred at −78° C. Butyllithium (1.6M, 0.42 mL) was added dropwise over 2 min. and then the reaction mixture was allowed to stir at 0° C. for 1.5 hours. The solution was cooled again to −78° C., treated dropwise with a solution of 2,6-diisopropyl-4-(4-fluorophenyl)-5-pentyl-3-pyridinecarboxaldehyde (Example 114, Step A) in 5 mL of dry THF, and then stirred at 0° C. for 2.5 hours. The reaction was quenched with water (10 mL) and the THF evaporated in vacuo. Diethyl ether was added and the mixture was washed with water (2×20 mL), brine (1×20 mL), and dried with MgSO4. Filtration, concentration and flash chromatography (30% CH2Cl2/hexanes) yielded a solid (0.132 g, 0.37 mmol, 66%). 1H NMR (300 MHz, CDCl3) δ 7.08 (m, J=1.1 Hz, 4 H), 6.34, 6.28 (d, J=11.4 Hz, J=11.4 Hz, 1 H), 5.19 (d, J=1.8 Hz, 1 H), 4.96 (d, J=1.8 Hz, 1 H), 3.39 (septet, J=6.6 Hz, 1 H), 3.24 (septet, J=6.6 Hz, 1 H), 2.30 (t, J=5.2 Hz, 2 H), 1.20 (m, J=2.2 Hz, 18 H), 0.979 (t, J=6.0 Hz, 3 H). FAB-MS: calcd for (C24H32FN) 353, found 354 (M+H). Anal. Calcd for C24H32FN: C, 81.54; H, 9.12; N, 3.96; F, 5.37. Found: C, 81.46; H, 9.06; N, 3.78; F, 5.59. mp 44-46° C. Rf=0.7 (30% CH2Cl2/hexanes).

후처리

  1. stirringto stir at 0° C. for 1.5 hours
  2. temperatureThe solution was cooled again to −78° C.
  3. stirringstirred at 0° C. for 2.5 hours
  4. customThe reaction was quenched with water (10 mL)
  5. customthe THF evaporated in vacuo
  6. additionDiethyl ether was added
  7. washthe mixture was washed with water (2×20 mL), brine (1×20 mL)
  8. dry with materialdried with MgSO4
  9. filtrationFiltration, concentration and flash chromatography (30% CH2Cl2/hexanes)

출처 및 근거

ORD 기록
ord-16eabe2b5a7e4b65a8753fb204e3696d
출처 데이터셋
uspto-grants-2001_04
특허 번호
US06218431B1

연결된 노트

불러오는 중…