Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(3-Methoxyphenyl)acetic acid → HCID 178490183, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (3-Methoxyphenyl)acetic acid | HCID 15719 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| 반응물 | HCID 178507147 | HCID 178507147 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | HCID 178490183 | HCID 178490183 | — |
반응 단계
The carboxylic acid of choice (3-methoxyphenyl acetic acid, 0.055 mmol) and 0.055 mmol of HBTU were dissolved in 0.5 mL amine-free DMF. To this solution was added dropwise a solution of 4-Amino-3-(4-aminophenyl)furo[2,3-d]pyrimidine (9) in 0.5 mL DMF. The resulting solution was treated with 0.024 mL of N,N-diisopropylethylamine. The system was stirred at room temperature overnight and then was concentrated to dryness in a Speedvac system, reconstituted in 1 mL DMSO and purified by prep HPLC to give the title compound. MS(ES) m/e 375 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07427623B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-facc5f6205ee441691fc7c0a9cd12ada |
| 출처 메모 | uspto-grants-2008_09 |