2-Chloro-3-pyridylamine → N-(2-chloropyridin-3-yl)-3-dimethylamino-1,2,3,4-tetrahydro-9H-carbazole-6-carboxamide

반응식

[CH3:1][N:2]([CH3:19])[CH:3]1[CH2:15][C:14]2[C:13]3[C:8](=[CH:9][CH:10]=[C:11]([C:16]([OH:18])=O)[CH:12]=3)[NH:7][C:6]=2[CH2:5][CH2:4]1.[Cl:20][C:21]1[C:26]([NH2:27])=[CH:25][CH:24]=[CH:23][N:22]=1>>[Cl:20][C:21]1[C:26]([NH:27][C:16]([C:11]2[CH:12]=[C:13]3[C:8](=[CH:9][CH:10]=2)[NH:7][C:6]2[CH2:5][CH2:4][CH:3]([N:2]([CH3:1])[CH3:19])[CH2:15][C:14]3=2)=[O:18])=[CH:25][CH:24]=[CH:23][N:22]=1

참가 물질

반응물 2

HCID 805282-Chloro-3-pyridylamine

HCID 123618113-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxylic acid

생성물 1

HCID 15512579N-(2-chloropyridin-3-yl)-3-dimethylamino-1,2,3,4-tetrahydro-9H-carbazole-6-carboxamide수율 9%

실험 절차

Beginning with 7.4 mg (0.029 mMol) 3-dimethylamino-1,2,3,4-tetrahydro-9H-carbazole-6-carboxylic acid and 2-chloro-3-aminopyridine, 1.2 mg (9%) of the title compound were recovered.

출처 및 근거

ORD 기록: ord-117b3771aa6e4c3d860e483b1ecdeb1c
출처 데이터셋: uspto-grants-2001_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06221884B1

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