5,5-Dimethyl-2,4-imidazolidinedithione → 2,4-bis-(4-dimethylaminobenzylthio)-5,5-dimethyl-5H-imidazole

HRID 3250노트

반응식

HRID 3250 반응식
Cl.[CH3:2][N:3]([CH3:12])[C:4]1[CH:11]=[CH:10][C:7]([CH2:8]Cl)=[CH:6][CH:5]=1.[CH3:13][C:14]1([CH3:21])[NH:18][C:17](=[S:19])[NH:16][C:15]1=[S:20]>C(O)C>[CH3:2][N:3]([CH3:12])[C:4]1[CH:11]=[CH:10][C:7]([CH2:8][S:19][C:17]2[N:16]=[C:15]([S:20][CH2:8][C:7]3[CH:10]=[CH:11][C:4]([N:3]([CH3:12])[CH3:2])=[CH:5][CH:6]=3)[C:14]([CH3:21])([CH3:13])[N:18]=2)=[CH:6][CH:5]=1

참가 물질

4

반응물 2

HCID 30021425,5-Dimethyl-2,4-imidazolidinedithioneHCID 189348744-(chloromethyl)-N,N-dimethylaniline hydrochloride

생성물 1

HCID 189348412,4-bis-(4-dimethylaminobenzylthio)-5,5-dimethyl-5H-imidazole

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Initially, 3.2 g of 4-dimethylaminobenzylchloride hydrochloride was added to a solution of 1 g of 5,5-dimethyl-2,4-dithiohydantoin in 50 mL of ethanol (EtOH). The reaction mixture was treated following the procedure used in Example 62, and purified by column chromatography (CHCl3). Recrystallization form diethyl ether-n-hexane gave the desired compound in the form of a needle-like crystal. The yield of this compound was 1.9 g with a yield ratio of 71.2%, and the melting point was 91°-92° C.

후처리

  1. additionThe reaction mixture was treated
  2. custompurified by column chromatography (CHCl3)
  3. customRecrystallization
  4. customform diethyl ether-n-hexane

출처 및 근거

ORD 기록
ord-6f30ba70e6f749ca9b50c7fefb87d362
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05733922

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