Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triphenylphosphine → [2-(4-Cyanophenyl)ethoxy]-4-methyl-3-nitrobenzene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triphenylphosphine | HCID 11776 | — |
| 반응물 | 3-Nitro-p-cresol | HCID 16271 | — |
| 반응물 | 4-(2-Hydroxyethyl)benzonitrile | HCID 2800815 | — |
| 반응물 | Diethyl azodicarboxylate | HCID 5462977 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | [2-(4-Cyanophenyl)ethoxy]-4-methyl-3-nitrobenzene | HCID 22033464 | — |
반응 단계
4-Methyl-3-nitrophenol (0.765 g; 5.0 mmol), 2-(4-cyanophenyl)ethanol (0.735 g; 5.0 mmol) and diethylazodicarboxylate (0.87 g; 5.0 mmol) were dissolved in THF (20 mL). Triphenylphosphine (1.31 g; 5.0 mmol), dissolved in THF (5 mL), was added and the solution stirred overnight. Evaporation in vacuo and the addition of diethyl ether afforded a yellow solid that was recrystallized from water:acetone (9:1), affording the sub-title compound as yellowish crystals. Yield: 1.04 g (74%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06221898B1 |
| 출처 데이터셋 | uspto-grants-2001_04 |
| ORD ID | ord-d970b539f2dc42ef96a33271cf91092f |
| 출처 메모 | uspto-grants-2001_04 |