Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Orcinol → 3-[2-(4-Cyanophenyl)ethoxy]-5-methylphenol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Orcinol | HCID 10436 | — |
| 반응물 | Triphenylphosphine | HCID 11776 | — |
| 반응물 | 4-(2-Hydroxyethyl)benzonitrile | HCID 2800815 | — |
| 반응물 | Diethyl azodicarboxylate | HCID 5462977 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 3-[2-(4-Cyanophenyl)ethoxy]-5-methylphenol | HCID 22033530 | 37% |
반응 단계
Triphenylphoshine (7.86 g; 30 mmol), 3,5-dihydroxytoluene (2.5 g; 20 mmol) and 2-(4-cyanophenyl)ethanol (4.41 g; 30 mmol) were dissolved in THF (50 mL). Diethylazodicarboxylate (5.22 g; 30 mmol; dissolved in THF (10 mL)), was added and the solution was stirred at room temperature overnight. The solvent was removed in vacuo and the white solid residue extracted with Et2O. Purification by flash chromatography (SiO2; toluene:EtOAc (10:1)) afforded 1.85 g (37%) of the sub-title compound as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06221898B1 |
| 출처 데이터셋 | uspto-grants-2001_04 |
| ORD ID | ord-c75018db129c4a1882a1a70317255148 |
| 출처 메모 | uspto-grants-2001_04 |