Thionyl Chloride → 6-Cyanonaphthalene-2-carbonyl chloride

HRID 325064노트

반응식

HRID 325064 반응식
[C:1]([C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([C:13]([OH:15])=O)[CH:7]=[CH:6]2)#[N:2].S(Cl)([Cl:18])=O.S([O-])([O-])(=O)=O.[Ca+2]>CN(C=O)C>[C:1]([C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([C:13]([Cl:18])=[O:15])[CH:7]=[CH:6]2)#[N:2]

참가 물질

5

반응물 3

HCID 24386Thionyl ChlorideHCID 24497Calcium SulfateHCID 124330906-Cyanonaphthalene-2-carboxylic acid

생성물 1

HCID 124330916-Cyanonaphthalene-2-carbonyl chloride

시약·촉매·용매 1

HCID 6228Dimethylformamide촉매

실험 절차

A mixture of 6-cyano-naphthalene-2-carboxylic acid (250.00 mg, 1.27 mmol), thionyl chloride (15 mL), and a few drops of DMF was refluxed for two hours under a condenser equipped with a drying tube containing anhydrous calcium sulfate. The thionyl chloride was then removed by high vacuum distillation, yielding a quantitative yield of a yellow solid. This material was not characterized, and was carried on without further purification.

후처리

  1. temperaturewas refluxed for two hours under a condenser
  2. customequipped with a drying tube
  3. customThe thionyl chloride was then removed by high vacuum distillation

출처 및 근거

ORD 기록
ord-aca9966e54ec44b29a6523fcf589028a
출처 데이터셋
uspto-grants-2001_04
특허 번호
US06221914B1

반응 노트

불러오는 중…