Benzyl Bromide → HCID 178418227, 화합물

HRID 3251

반응식

HRID 3251 반응식
[CH2:1](Br)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:9][C:10]1([CH3:17])[NH:14][C:13](=[S:15])[NH:12][C:11]1=[S:16]>C(O)C>[CH2:1]([S:15][C:13]1[NH:14][C:10]([CH3:17])([CH3:9])[C:11](=[S:16])[N:12]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 7498Benzyl BromideHCID 30021425,5-Dimethyl-2,4-imidazolidinedithione

생성물 1

HCID 178418227HCID 178418227, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Initially, 1.91 mL of benzylbromide was added to a solution of 1.6 g of 5,5-dimethyl-2,4-dithiohydantoin in 50 mL of ethanol (EtOH). The reaction mixture was stirred at the room temperature for one hour, and concentrated in vacuo. The residue was treated following the procedure used in Example 62, and purified by column chromatography (CHCl3). Recrystallization from diethyl ether-n-hexane gave 2-benzylthio-5,5-dimethylimidazolin-4-thione in the form of a needle-like crystal. The yield of this compound was 0.87 g with a yield ratio of 34.8%, and the melting point was 133°-134° C.

후처리

  1. concentrationconcentrated in vacuo
  2. additionThe residue was treated
  3. custompurified by column chromatography (CHCl3)
  4. customRecrystallization from diethyl ether-n-hexane

출처 및 근거

ORD 기록
ord-2f49fa4e191649188ac77496c1af416a
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05733922

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