Dimethyl malonate → HCID 54377802, 화합물

HRID 325132

반응식

HRID 325132 반응식
[C:1]([O:8][CH3:9])(=[O:7])[CH2:2][C:3]([O:5][CH3:6])=[O:4].C(O)[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH:18]=[CH2:19].C[O-].[Na+]>CO>[CH2:6]([O:5][C:3](=[O:4])[CH2:2][C:1]([O:8][CH2:9][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH:18]=[CH2:19])=[O:7])[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH:12]=[CH2:11]

참가 물질

5

반응물 3

HCID 7943Dimethyl malonateHCID 256129-Decen-1-olHCID 10942334Sodium Methoxide

생성물 1

HCID 54377802HCID 54377802, 화합물수율 59.7%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a mixture of 150 g dimethyl malonate and 464 g dec-9-en-1-ol, 30 g sodium methoxide (5.4 M in methanol) was dropped in. The mixture was heated to 120° C. to and the methanol formed was distilled off. After 6 hours, the mixture was cooled down, diluted with ether and washed with HCl 2N, saturated sodium bicarbonate and water. The organic phase was dried, filtered and evaporated to dryness. The resulting yellow oil was purified by distillation to yield 258 g of a yellow oil.

후처리

  1. additionwas dropped in
  2. customformed
  3. distillationwas distilled off
  4. temperaturethe mixture was cooled down
  5. additiondiluted with ether
  6. washwashed with HCl 2N, saturated sodium bicarbonate and water
  7. customThe organic phase was dried
  8. filtrationfiltered
  9. customevaporated to dryness
  10. distillationThe resulting yellow oil was purified by distillation

출처 및 근거

ORD 기록
ord-c1c18be20e8b487fb1171076433c2256
출처 데이터셋
uspto-grants-2001_04
특허 번호
US06222062B1

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