4-tert-Butylcyclohexanone → 4-Tert-butyl-1,1-difluorocyclohexane
반응식
[C:1]([CH:5]1CCC(=O)CC1)(C)([CH3:3])[CH3:2].C(N(S(F)(F)[F:18])CC)C.[F:21][C:22]1[CH:27]=[CH:26][C:25](OC)=[CH:24][CH:23]=1>C(Cl)Cl>[F:21][C:22]1([F:18])[CH2:27][CH2:26][CH:25]([C:1]([CH3:5])([CH3:3])[CH3:2])[CH2:24][CH2:23]1참가 물질
5
실험 절차
A reaction of 4-t-butylcyclohexanone (2 mmol) with diethylaminosulfur trifluoride (3.0 mmol) in CH2Cl2 (10 mL) containing Znl2 (0.3 mmol) at room temperature gave a 99% conversion of starting material to products and a 67% yield of 1,1-difluoro-4-t-butylcyclohexane after 6 h. as determined by NMR (4-fluoroanisole as internal standard).
후처리
- additioncontaining Znl2 (0.3 mmol) at room temperature
- customgave a 99% conversion of starting material to products
출처 및 근거
- ORD 기록
- ord-9bb3f278c5cd459ab794e3e342a1e672
- 출처 데이터셋
- uspto-grants-2001_04
- 특허 번호
- US06222064B1
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