Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Bromide ion → 2-Allylphenol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Bromide ion | HCID 259 | — |
| 반응물 | Phenol | HCID 996 | — |
| 반응물 | Diethyl Ether | HCID 3283 | — |
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 생성물 | 2-Allylphenol | HCID 15624 | — |
반응 단계
Phenol 25 may be treated with NaH in DMF and then alkylated with an allylic bromide to give ether 30. Claisen rearrangement of 30 under thermal conditions gives ortho-allyl phenol 31. Oxidation of the double bond in 31 with OsO4/NMO followed by cleavage with NaIO4 provides the lactol 32. Jones oxidation then provides lactone 33.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06222048B1 |
| 출처 데이터셋 | uspto-grants-2001_04 |
| ORD ID | ord-b7d538998ef745339debbef27317b340 |
| 출처 메모 | uspto-grants-2001_04 |