Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diethylamine → {4-[2-(Imidazol-2-yl)ethynyl]-2-phenylbenzoyl}-methionine methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diethylamine | HCID 8021 | — |
| 반응물 | (4-Ethynyl-2-phenylbenzoyl)methionine methyl ester | HCID 54338681 | — |
| 반응물 | HCID 178418934 | HCID 178418934 | — |
| 촉매 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 촉매 | Palladium(2+) acetate--triphenylphosphane (1/2/2) | HCID 84538 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | {4-[2-(Imidazol-2-yl)ethynyl]-2-phenylbenzoyl}-methionine methyl ester | HCID 69930468 | — |
반응 단계
The resultant product from Example 47A (5 mmol) is mixed with 4-bromoimidazole (5 mmol), diethylamine (1 mL), bis(triphenylphosphine) palladium diacetate (0.1 mmol) and copper(I) iodide (0.1 mmol) in toluene. The mixture is stied at 25° C. until TLC analysis indicates the reaction is complete. The reaction mixture is concentrated in vacuo, and the residue is purified with column chromatography on silica gel to give the title product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06221865B1 |
| 출처 데이터셋 | uspto-grants-2001_04 |
| ORD ID | ord-5ea27226ef3a42f78a7d8d7d2e59401e |
| 출처 메모 | uspto-grants-2001_04 |