Diketene → N-acetoacetyl-L-aspartyl-L-phenylalanine methyl ester

HRID 325273

반응식

HRID 325273 반응식
[CH2:1]=[C:2]1[O:6][C:4](=[O:5])[CH2:3]1.[CH3:7][O:8][C:9](=[O:27])[C@H:10]([CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[NH:11][C:12](=[O:19])[C@H:13]([CH2:15][C:16](=[O:18])[OH:17])[NH2:14]>O1CCCC1>[CH3:7][O:8][C:9](=[O:27])[C@H:10]([CH2:20][C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)[NH:11][C:12](=[O:19])[C@H:13]([CH2:15][C:16](=[O:17])[OH:18])[NH:14][C:4](=[O:5])[CH2:3][C:2]([CH3:1])=[O:6]

참가 물질

4

반응물 2

HCID 12661Diketene2회HCID 134601Aspartame

생성물 1

HCID 13334676N-acetoacetyl-L-aspartyl-L-phenylalanine methyl ester

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

4.5 parts of diketene were added dropwise to a stirred suspension of 14.7 parts α-L-aspartyl-L-phenylalanine methyl ester in 400 parts by volume of tetrahydrofuran and stirred for 20 hours at ambient temperatures. An additional 4.2 parts of diketene was added. After 18 hours, the solvent was removed under vacuum and the residue was purified by chromotography on silica gel to give N-acetoacetyl-α-L-aspartyl-L-phenylalanine methyl ester, mp. 118.5°-121° C. which eluted in a 10:90:0.1 ethanol:methylene chloride:acetic acid mixture.

후처리

  1. waitAfter 18 hours
  2. customthe solvent was removed under vacuum
  3. customthe residue was purified by chromotography on silica gel

출처 및 근거

ORD 기록
ord-b2881bece4c24faa94fa579e10d8d880
출처 데이터셋
uspto-grants-1984_04
특허 번호
US04440677

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