Sodium methanethiolate → 6-Methyl-4-(methylthio)thieno[3,2-d]pyrimidine

HRID 32532노트

반응식

HRID 32532 반응식
[CH3:1][S-:2].[Na+].[CH3:4][C:5]1[S:13][C:12]2[C:11](Cl)=[N:10][CH:9]=[N:8][C:7]=2[CH:6]=1>C(#N)C>[CH3:4][C:5]1[S:13][C:12]2[C:11]([S:2][CH3:1])=[N:10][CH:9]=[N:8][C:7]=2[CH:6]=1

참가 물질

4

반응물 2

HCID 4378561Sodium methanethiolateHCID 136832234-Chloro-6-methylthieno[3,2-d]pyrimidine

생성물 1

HCID 179658316-Methyl-4-(methylthio)thieno[3,2-d]pyrimidine수율 97%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A solution of sodium thiomethoxide (24S mg) and 6-methyl-4-chlorothieno[3,2-d]pyrimidine (Acta Pol. Pharm. (1986), 43(2), 97-100) (650 mg) in acetonitrile (50 mL) was stirred overnight. The mixture was filtered and the solid was washed with acetonitrile. The combined filtrate and washes were evaporated to give the title compound as a white solid (665 mg, 97%);

후처리

  1. filtrationThe mixture was filtered
  2. washthe solid was washed with acetonitrile
  3. customThe combined filtrate and washes were evaporated

출처 및 근거

ORD 기록
ord-bfa91bba01444c858e262522dcf3c6d5
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07427616B2

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