Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonia → 4-Amino-7-trifluoromethylimidazo[1,5-a]quinoxaline 3-carboxylic acid ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | 4-Chloro-7-trifluoromethylimidazo[1,5-a]quinoxaline 3-carboxylic acid ethyl ester | HCID 54209491 | — |
| 용매 | Chloroform ethanol | HCID 21889567 | — |
| 생성물 | 4-Amino-7-trifluoromethylimidazo[1,5-a]quinoxaline 3-carboxylic acid ethyl ester | HCID 13309917 | 57% |
반응 단계
A small stream of anhydrous ammonia was passed through a solution of 4-chloro-7-trifluoromethylimidazo[1,5-a]quinoxaline 3-carboxylic acid ethyl ester (5.4 g) in chloroform-ethanol (100 ml each) for 30 minutes. The precipitate was collected and recrystallized from DMF to give the product as an off-white crystalline solid (2.9 g, 57% yield), m.p. >300° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04440929 |
| 출처 데이터셋 | uspto-grants-1984_04 |
| ORD ID | ord-3ad0da183781423d81bd1213231b7b04 |
| 출처 메모 | uspto-grants-1984_04 |