Ammonia → 4-Amino-7-trifluoromethylimidazo[1,5-a]quinoxaline 3-carboxylic acid ethyl ester

HRID 325451

반응식

HRID 325451 반응식
[NH3:1].[CH2:2]([O:4][C:5]([C:7]1[N:8]=[CH:9][N:10]2[C:19]3[C:14](=[CH:15][C:16]([C:20]([F:23])([F:22])[F:21])=[CH:17][CH:18]=3)[N:13]=[C:12](Cl)[C:11]=12)=[O:6])[CH3:3]>C(Cl)(Cl)Cl.C(O)C>[CH2:2]([O:4][C:5]([C:7]1[N:8]=[CH:9][N:10]2[C:19]3[C:14](=[CH:15][C:16]([C:20]([F:23])([F:22])[F:21])=[CH:17][CH:18]=3)[N:13]=[C:12]([NH2:1])[C:11]=12)=[O:6])[CH3:3]

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 542094914-Chloro-7-trifluoromethylimidazo[1,5-a]quinoxaline 3-carboxylic acid ethyl ester

생성물 1

HCID 133099174-Amino-7-trifluoromethylimidazo[1,5-a]quinoxaline 3-carboxylic acid ethyl ester수율 57%

시약·촉매·용매 1

HCID 21889567Chloroform ethanol용매

실험 절차

A small stream of anhydrous ammonia was passed through a solution of 4-chloro-7-trifluoromethylimidazo[1,5-a]quinoxaline 3-carboxylic acid ethyl ester (5.4 g) in chloroform-ethanol (100 ml each) for 30 minutes. The precipitate was collected and recrystallized from DMF to give the product as an off-white crystalline solid (2.9 g, 57% yield), m.p. >300° C.

후처리

  1. customThe precipitate was collected
  2. customrecrystallized from DMF

출처 및 근거

ORD 기록
ord-3ad0da183781423d81bd1213231b7b04
출처 데이터셋
uspto-grants-1984_04
특허 번호
US04440929

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