Tert-butyl 2-(cyclopentylamino)acetate → N-(2-Acetylthio-3-methylbenzoyl)-N-cyclopentylglycine t-butyl ester

HRID 325489노트

반응식

HRID 325489 반응식
[C:1]([O:5][C:6](=[O:14])[CH2:7][NH:8][CH:9]1[CH2:13][CH2:12][CH2:11][CH2:10]1)([CH3:4])([CH3:3])[CH3:2].[C:15]([S:18][C:19]1[C:27]([CH3:28])=[CH:26][CH:25]=[CH:24][C:20]=1[C:21](O)=[O:22])(=[O:17])[CH3:16]>C(Cl)Cl>[C:1]([O:5][C:6](=[O:14])[CH2:7][N:8]([C:21](=[O:22])[C:20]1[CH:24]=[CH:25][CH:26]=[C:27]([CH3:28])[C:19]=1[S:18][C:15](=[O:17])[CH3:16])[CH:9]1[CH2:10][CH2:11][CH2:12][CH2:13]1)([CH3:4])([CH3:2])[CH3:3]

참가 물질

4

반응물 2

HCID 13298943Tert-butyl 2-(cyclopentylamino)acetateHCID 204652132-Acetylthio-3-methylbenzoic acid

생성물 1

HCID 20465218N-(2-Acetylthio-3-methylbenzoyl)-N-cyclopentylglycine t-butyl ester

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

반응 조건

온도
0 °C

실험 절차

N-Cyclopentylglycine t-butyl ester (8.3 g, 0.042 mole) and 2-acetylthio-3-methylbenzoic acid (8.9 g, 0.042 mole) were combined in 90 ml CH2Cl2. This solution was cooled to 0° C. before adding to it a solution of N,N-dicyclohexylcarbodiimide (8.6 g, 0.042 mole) in 30 ml CH2Cl2 dropwise over 15 minutes. The reaction was allowed to warm slowly to room temperature overnight.

후처리

  1. temperatureto warm slowly to room temperature overnight

출처 및 근거

ORD 기록
ord-55004cc9fd5d472c8dbaa8bd9cb6e1a1
출처 데이터셋
uspto-grants-1984_04
특허 번호
US04440941

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