Tert-butyl 2-(cyclopentylamino)acetate → HCID 20465235, 화합물

HRID 325501노트

반응식

HRID 325501 반응식
[Cl:1][CH2:2][C:3]([C:5]1[CH:13]=[CH:12][CH:11]=[C:7]([C:8]([OH:10])=O)[C:6]=1[OH:14])=[O:4].[C:15]([O:19][C:20](=[O:28])[CH2:21][NH:22][CH:23]1[CH2:27][CH2:26][CH2:25][CH2:24]1)([CH3:18])([CH3:17])[CH3:16]>C(Cl)Cl>[C:15]([O:19][C:20](=[O:28])[CH2:21][N:22]([C:8](=[O:10])[C:7]1[C:6](=[C:5]([C:3](=[O:4])[CH2:2][Cl:1])[CH:13]=[CH:12][CH:11]=1)[OH:14])[CH:23]1[CH2:24][CH2:25][CH2:26][CH2:27]1)([CH3:18])([CH3:16])[CH3:17]

참가 물질

4

반응물 2

HCID 13298943Tert-butyl 2-(cyclopentylamino)acetateHCID 20465232HCID 20465232, 화합물

생성물 1

HCID 20465235HCID 20465235, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

3-Chloroacetylsalicylic acid was combined with N-cyclopentylglycine t-butyl ester and N,N1 -dicyclohexylcarbodiimide at 0° C. in methylene chloride as described in Example I. Similar workup gave crude N-(3-chloroacetylsalicyloyl)-N-cyclopentylglycine t-butyl ester, which was cleaved to N-(3-chloroacetylsalicyloyl)-N-cyclopentylglycine using iodotrimethylsilane prepared in situ as described in Example I. Hydrolysis with aqueous sodium hydroxide (Example IV) provided the title compound.

출처 및 근거

ORD 기록
ord-c4873401acee48838b7d6e2f4e8daaf2
출처 데이터셋
uspto-grants-1984_04
특허 번호
US04440941

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