Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanesulfonic Acid → 5-[(4-Aminobutoxy)methyl]-N,N-dimethyl-2-furanmethanamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanesulfonic Acid | HCID 6395 | — |
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 4-Amino-1-butanol | HCID 25868 | — |
| 반응물 | 5-((Dimethylamino)methyl)-2-furanmethanol | HCID 84906 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 5-[(4-Aminobutoxy)methyl]-N,N-dimethyl-2-furanmethanamine | HCID 21297583 | 29.2% |
반응 단계
A mixture of methanesulphonic acid (86 g), 5-[(dimethylamino)methyl]-2-furanmethanol (15.5 g) and 4-aminobutanol (17.8 g) in dry tetrahydrofuran was heated at 100° for 11/2 h. Excess sodium carbonate was added to the cooled solution, the suspension was filtered and the filtrate was evaporated to give a red oil which was dissolved in water and extracted with ether. The extract was distilled to give the title compound as an oil (6.6 g) b.p. 100°-110°, 0.08 mm. TLC silica, methanol/ammonia 0.88 80:1, Rf 0.3.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04442110 |
| 출처 데이터셋 | uspto-grants-1984_04 |
| ORD ID | ord-8cb39d9f874f4a81919a2728623b39b0 |
| 출처 메모 | uspto-grants-1984_04 |