Nitric Acid → 2-Hydroxy-3-nitrobiphenyl

HRID 325851

반응식

HRID 325851 반응식
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[N+:14]([O-])([OH:16])=[O:15]>C(O)(=O)C>[OH:1][C:2]1[C:7]([N+:14]([O-:16])=[O:15])=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1

참가 물질

4

반응물 2

HCID 944Nitric AcidHCID 7017(1,1'-Biphenyl)-2-ol

생성물 1

HCID 1607452-Hydroxy-3-nitrobiphenyl

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

In step (1) of Reaction Scheme 1, a 2-hydroxybiphenyl of Formula II is nitrated using nitric acid in the presence of acetic acid to provide a 2-hydroxy-3-nitrobiphenyl of Formula III. A preferred method of carrying out this reaction is as follows. The biphenyl of Formula II is dissolved in glacial acetic acid at a temperature of 15° to 20° C. Concentrated nitric acid is then added thereto and the resulting mixture is stirred for a short period of time (usually less than about one hour). Thereafter the mixture is diluted with an equal volume of water. The 2-hydroxy-3-nitrobiphenyl of Formula III is separated from the mixture, usually as an oil, and is triturated with hot hexane and purified by chromotography. As an alternative to conducting step (1), known 2-hydroxy-3-nitrobiphenyls may be employed directly in step (2) below.

후처리

  1. customIn step (1) of Reaction Scheme 1

출처 및 근거

ORD 기록
ord-3401282207604bef9da74f7e1dfb5408
출처 데이터셋
uspto-grants-1984_04
특허 번호
US04443447

연결된 노트

불러오는 중…