Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Aminopyrrolidine → 2-[1-(Cyclohexylmethyl)-4-phenyl-1H-imidazol-5-yl]-7-(methylthio)[1,3]thiazolo[5,4-d]pyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Aminopyrrolidine | HCID 164401 | — |
| 반응물 | 7-(Methylthio)[1,3]thiazolo[5,4-d]pyrimidine-2-carbaldehyde | HCID 17965798 | — |
| 반응물 | 4-Aminothieno[2,3-d]pyrimidine-6-carbaldehyde | HCID 17965819 | — |
| 반응물 | 1-(cyclohexylmethyl)-4,5-diphenyl-1H-imidazole | HCID 69194873 | — |
| 생성물 | 2-[1-(Cyclohexylmethyl)-4-phenyl-1H-imidazol-5-yl]-7-(methylthio)[1,3]thiazolo[5,4-d]pyrimidine | HCID 69194440 | — |
반응 단계
The title compound was prepared by a similar process to that described for Example 65 but using 7-(methylthio)[1,3]thiazolo[5,4-d]pyrimidine-2-carbaldehyde (Intermediate 77) in place of 4-aminothieno[2,3-d]pyrimidine-6-carbaldehyde (Intermediate 73) and using cyclohexamethylamine in place of 3-aminopyrrolidine. Yellow solid (542 mg) (the product contained 33% of 1-(cyclohexylmethyl)-4,5-diphenyl-1H-imidazole but was used in subsequent steps without further purification);
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07427616B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-cd391bac60304d50bd71986e166b797d |
| 출처 메모 | uspto-grants-2008_09 |