참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrogen iodide | HCID 24841 | — |
| 반응물 | 4,5-Pyrimidinediamine, 6-chloro- | HCID 78010 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 생성물 | 6-Iodopyrimidine-4,5-diamine | HCID 17965894 | 98% |
반응 단계
6-Chloropyrimidine-4,5-diamine (Intermediate 88) (90 mg) was added slowly to HI (57%, aq) (2 mL) at 0° C. The reaction mixture was allowed to stir at 0° C. for 30 minutes and then at ambient temperature for 24 hours. NaHCO3 (sat aq.) was added dropwise until the reaction mixture was pH 8. The product was extracted with EtOAc (3×15 mL). The combined organics were dried (MgSO4), filtered and concentrated in vacuo to afford the title compound as a grey solid (144 mg, 98%);
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07427616B2 |
|---|
| 출처 데이터셋 | uspto-grants-2008_09 |
|---|
| ORD ID | ord-36d650d9bef54b7e970ce0e95d3a1b3e |
|---|
| 출처 메모 | uspto-grants-2008_09 |
|---|
