1-Chloro-2-(diethylamine)ethane hydrochloride → 2-(2-{[2-(Dimethylamino)ethyl]thio}-1-methyl-4-phenyl-1H-imidazol-5-yl)[1,3]thiazolo[5,4-d]pyrimidin-7-amine

https://huagongshe.com/ko/reaction/32610

참여 물질

역할	이름	HCID	투입량
반응물	1-Chloro-2-(diethylamine)ethane hydrochloride	HCID 13363	—
반응물	Sodium Hydroxide	HCID 14798	—
반응물	HCID 178481673	HCID 178481673	—
생성물	2-(2-{[2-(Dimethylamino)ethyl]thio}-1-methyl-4-phenyl-1H-imidazol-5-yl)[1,3]thiazolo[5,4-d]pyrimidin-7-amine	HCID 10476741	—

반응 조건

온도	60 °C

반응 단계

A mixture of 5-(7-amino[1,3]thiazolo[5,4-d]pyrimidin-2-yl)-1-methyl-4-phenyl-1H-imidazole-2-thiol (Intermediate 47) (10 mg), N,N-diethyl-2-chloroethylamine hydrochloride (9 mg) and 2M NaOH (1 mL) was heated at 60° C. for 6 hours. After which the reaction mixture was cooled to ambient temperature and the title compound isolated by filtration as a yellow solid (6 mg, 50%);

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07427616B2
출처 데이터셋	uspto-grants-2008_09
ORD ID	ord-fac9286b65b842e4b6bda091b4d6796d
출처 메모	uspto-grants-2008_09