Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Cyanide → Hydrochloric Acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Cyanide | HCID 9032 | — |
| 반응물 | Dibenzo-18-crown-6 | HCID 26541 | — |
| 반응물 | 5-(5-Chloropentyl)imidazo[1,5-a]pyridine | HCID 20446676 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | Hydrochloric Acid | HCID 313 | — |
| 생성물 | 5-(5-Cyanopentyl)-imidazo[1,5-a]pyridine hydrochloride | HCID 20446665 | — |
반응 단계
A solution of 37 g of 5-(5-chloropentyl)-imidazo[1,5-a]pyridine, 21.7 g of potassium cyanide and 3 g of dibenzo-18-crown-6 in acetonitrile is heated under reflux for 20 hours. The acetonitrile is evaporated under reduced pressure, the residue is partitioned between water and methylene chloride, and the methylene chloride extract is evaporated to dryness. Treatment of a solution of the residue in ether with ethanolic hydrochloric acid yields 5-(5-cyanopentyl)-imidazo[1,5-a]pyridine hydrochloride melting at 178°-80°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04444775 |
| 출처 데이터셋 | uspto-grants-1984_04 |
| ORD ID | ord-82c685267c444f88a9989255cbbb1444 |
| 출처 메모 | uspto-grants-1984_04 |