5-(5-Carboxypent-4-enyl)-imidazo[1,5-a]pyridine → Pirmagrel

HRID 326129

반응식

HRID 326129 반응식
[C:1]([CH:4]=[CH:5][CH2:6][CH2:7][CH2:8][C:9]1[N:14]2[CH:15]=[N:16][CH:17]=[C:13]2[CH:12]=[CH:11][CH:10]=1)([OH:3])=[O:2]>CO.[Pd]>[C:1]([CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][C:9]1[N:14]2[CH:15]=[N:16][CH:17]=[C:13]2[CH:12]=[CH:11][CH:10]=1)([OH:3])=[O:2]

참가 물질

4

반응물 1

HCID 538080535-(5-Carboxypent-4-enyl)-imidazo[1,5-a]pyridine

생성물 1

HCID 55390Pirmagrel

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a solution of 150 mg of 5-(5-carboxypent-4-enyl)-imidazo[1,5-a]pyridine in 7 ml methanol is added 100 mg of 10% palladium on carbon as catalyst. The reaction mixture is hydrogenated at atmospheric pressure for 3 hours. The catalyst is removed by filtration and the solvent evaporated under reduced pressure to yield 5-(5-carboxypentyl)-imidazo[1,5-a]pyridine melting at 144°-7°, and identical to the product of Example 2.

후처리

  1. customThe catalyst is removed by filtration
  2. customthe solvent evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-4e20b28dbeee41708cc00e3314c66d4b
출처 데이터셋
uspto-grants-1984_04
특허 번호
US04444775

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