참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Glycidyl methacrylate | HCID 7837 | — |
| 반응물 | 2-[2-(4-Hydroxy-3-methoxyphenyl)-ethenyl]-quinoline | HCID 623970 | — |
| 촉매 | Tetrabutylammonium Chloride | HCID 70681 | — |
| 용매 | Dimethylacetamide | HCID 31374 | — |
| 생성물 | 2-{2-[3-Methoxy-4-(2-hydroxy-3-methacryloyloxypropyloxy)-phenyl]-ethenyl}-quinoline | HCID 54327940 | 50% |
반응 단계
In 5 cm3 of N,N-dimethylacetamide, 2.77 g of the produced quinoline derivative was dissolved and 1.42 g of glycidyl methacrylate and 0.10 g of tetrabutylammonium chloride were added thereto. The resultant mixture was reacted by maintaining it at 90° to 100° C. for 5 hours. The reaction product was mixed with water. The oily substance separated consequently was extracted via ethyl acetate, washed thoroughly with water, and dried. The dry product was distilled to expel the solvent and then separated and purified by silica gel chromatography, to afford 2-{2-[3-methoxy-4-(2-hydroxy-3-methacryloyloxypropyloxy)-phenyl]-ethenyl}-quinoline in a yield of 50%. When this product was recrystallized via ethyl acetatehexane, there was obtained a pure product having a melting point of 119° C. It was identified by elementary analysis and infrared absorption spectrometry.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US04444868 |
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| 출처 데이터셋 | uspto-grants-1984_04 |
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| ORD ID | ord-937b96f9883c4dc3af7a5c24d204bfd7 |
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| 출처 메모 | uspto-grants-1984_04 |
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